There’s a simple way to turn it off, thankfully, although I’d recommend you leave it on the majority of the time.

Just right-click on your Recycle Bin and choose Properties from the menu.

Now you’ll see the Trash Properties dialog, and notice the “Display delete confirmation dialog” at the bottom.

Just uncheck the box, and close the dialog. No more confirmations!  (I’d still recommend that you turn it back on when you are done cleaning up your computer)